Hoffmann-Chen实验室
Hoffmann-Chen实验室
（Hoffmann-Chen Lab）
1. 负责人简介（Introduction of Team Leader）
Jules Hoffmann教授
Jules Hoffmann教授是2011年诺贝尔生理学或医学奖的得主，目前是斯特拉斯堡大学的终身教授，广州医科大学霍夫曼免疫研究所名誉所长以及特聘教授，法国科学院以及法兰西学院的两院院士，德国国家科学院、俄罗斯国家科学院以及美国癌症研究协会院士。2013年Jules Hoffmann教授与广州医科大学合作签订协议，建立霍夫曼免疫研究所（Sino-French Hoffmann Institute），2019年10月Hoffmann教授联合陈笛副研究员以及Akira Goto(法国国家健康与医学研究中心副教授，终身职位，广州医科大学特聘教授)在霍夫曼免疫研究所设立以果蝇为模型的天然免疫抗肿瘤机制研究课题组，目前课题经费充足。研究所以昆虫为模型研究天然免疫机制相关的分子以及遗传机制。（网站https://sfhi.gzhmu.edu.cn/Hoffmann）2011年，由于他对于天然免疫激活机制的重要发现，与Bruce Beutler教授以及Ralph Steinman教授共同获得诺贝尔生理学或医学奖。此外，Jules Hoffmann教授还是法兰西荣誉军团军官和法兰西学院的“不朽者”(法兰西学院院士)。他及其同事的研究开启了人们对天然免疫在哺乳动物中的重要作用有了重新的认识。
中法霍夫曼研究所成立于2013年，是由法国国家科学研究中心和广州医科大学王新华教授共同创办的。
Introduction of Prof. Jules Hoffmann
Professor Jules Hoffmann is the Laureate of Nobel prize physiology or Medicine 2011. He is the professor of University of Strasbourg and senior researcher at Centre national de la recherche scientifique (CNRS). He is the academician of French academy of science and Académie française. He dedicated his work to the study of the genetic and molecular mechanisms responsible for innate immunity in insects. The work of Hoffman and associates has provided new insights into the defense mechanisms that organisms, from the most primitive up to humans, employ against infectious agents. By demonstrating the marked conservation of innate defense mechanisms between insects and humans, the work initiated by Hoffmann and his collaborators has led to a re-evaluation of the role of innate immunity in mammals. With Bruce A. Beutler and Ralph M. Steinman, Hoffmann was awarded the Nobel Prize for Medicine in 2011.
Sino-French Hoffmann institute was established in 2013 when Centre national de la recherche scientifique, France signed a collaboration memo with Guangzhou medical University through the introduction of professor and president Xinhua Wang.
陈笛副研究员
陈笛（Di Chen），广州医科大学广州霍夫曼免疫研究所副研究员，硕士导师。自2014年于加拿大西安大略大学获得博士学位后，即到广州医科大学就职。2017.08-2019.08,于法国斯特拉斯堡大学进行博士后研究，合作导师为诺贝尔得主Jules Hoffmann。并于2019年协助Jules Hoffmann教授在广州霍夫曼免疫研究所创立Jules Hoffmann课题组。主要研究方向为：以果蝇为模型，研究天然免疫对原癌细胞的识别及反应的分子机制。
Di Chen is an associate researcher at the Sino-French Hoffmann Institute (SFHI), Guangzhou Medical University. She has been working at Guangzhou Medical University since 2014, when she received her PhD from the University of Western Ontario in Canada. From August 2017 to August 2019, she spent two years as a postdoctoral researcher at the University of Strasbourg in France, under the co-supervisor of Nobel Laureate Jules Hoffmann. In 2019, She helped Professor Jules Hoffmann establish the Jules Hoffmann Research Group at SFHI. Her main research interest is to study the molecular mechanism of innate immune recognition and response to oncogenic cells using Drosophila melanogaster as a model.
2. 课题组研究方向（Research interests）
最近的研究表明先天免疫对预防癌症进展有一定的重要性。然而，在很大程度上先天免疫对肿瘤的识别和反应的详细机制仍然是未知的。黑腹果蝇(Drosophila melanogaster)已被证明是研究先天免疫的一个强有力的模型，因着先天免疫的主要效应因子和分子机制，如TOLL、IMD、NF-κB和Janus酪氨酸激酶/信号转导和转录激活因子(JAK/STAT)通路从昆虫到人类都是进化上相对保守的。此外，由于昆虫免疫仅依赖于先天免疫反应，这使其成为研究先天免疫抗癌症的简单而稳健的动物模型。我们的项目旨在探索先天性免疫对癌症的识别和反应的潜在机制。
Recently, innate immunity has been found to be also important against cancer progression. However, the detailed mechanism of recognition and reaction remains largely unknown. Drosophila melanogaster has proven to be a powerful model for the study of innate immunity since the major factors and mechanisms involved in innate immunity, such as TOLL, IMD, NF-κB and Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT) pathways are evolutionary conserved from insects to humans. Further, insect immunity only relies on innate immune response, which makes it a simple and robust animal model for studying innate immunity against cancer. Our project aim is to explore the potential mechanisms of recognition and response of innate immunity against cancer.
目前，霍夫曼教授是广州医科大学广州霍夫曼免疫研究所的名誉所长以及科学委员会主席。从2018学年度开始正式招收博士研究生。欢迎具有分子生物学、细胞生物学以及免疫学教育背景的学生申报。表现优异者，可以申请斯特拉斯堡与广州医科大学双博士学位。
具体请联系：
广州医科大学博士生报名系统：http://210.38.57.153/phd/
招生简章：http://210.38.57.78:8019/pub/yjsjy/jqjd/14997.htm
或陈笛：chenseptember@outlook.com
联系方式：020-37105627
3. 课题组代表文章（Selected publications）
1. Di Chen *, Xiao Lan , Xiaoming Huang , Jieqing Huang , Xiaojing Zhou , Jiyong Liu , Jules A Hoffmann*. Methuselah like 1, a Drosophila homologue of Mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies. PNAS, 2023, (in press).
2. Di Chen*, Xiao Lan, Xiaoming Huang, Jieqing Huang, Xiaojing Zhou, Zhichao Miao, Yuting Ma, Akira Goto, Shanming Ji, Jules A. Hoffmann*. Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila. Journal of Innate Immunity, 2023, 15:442–467.
3. Qingshuang Cai, Huimin Guo, Rong Fang, Yongzhi Hua, Yangyang Zhu, Xianrui Zheng, Jing Yan, Jiale Wang, Yixuan Hu, Chuchu Zhang, Chao Zhang, Renjie Duan, Fanrui Kong, Shikun Zhang, Di Chen*, Shanming Ji*. A Toll-dependent Bre1/Rad6-cact feedback loop in controlling host innate immune response. Cell Reports, 2022, 47.
4. Alexandre Cammarata-Mouchtouris, Adrian Acker, Akira Goto, Di Chen, Nicolas Matt *, Vincent Leclerc *. Dynamic Regulation of NF-_B Response in Innate Immunity:The Case of the IMD Pathway in Drosophila. Biomedicines, 2022, 10(2304).
5. Di Chen (#)*, Arghyashree Roychowdhury-Sinha, Pragya Prakash, Xiao Lan, Wenmin Fan, Akira Goto*, Jules A. Hoffmann*. A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defences. PNAS, 2021, 118.
6. Chuqin Huang, Rui Xu, Samuel Liégeois, Di Chen, Zi Li, Dominique Ferrandon. Differential requirements for Mediator complex subunits in Drosophila melanogaster host defense against fungal and bacterial pathogens. Frontiers Immunology, 2021, 11.
7. Hua Cai, Andreas Holleufer, Bine Simonsen, Juliette Schneider, Aurélie Lemoine, Hans-Henrik Gad, Jingxian Huang, Jieqing Huang, Di Chen, Tao Peng, João T. Marques, Rune Hartmann, Nelson Martins, Jean-Luc Imler. "2'3'-cGAMP triggers a STING- and NF-kappaB-dependent broad antiviral response in Drosophila." Sci Signal，2020, 13(660).
8. Hua Cai, Wenxia Yao, Jingxian Huang, Jing Xiao, Wenli Chen, Longbo Hu, Runming Mai, Mengdi Liang, Di Chen, Nan Jiang, Li Zhou, Tao Peng. Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein. Antiviral research, 2020, 177, 104756.
9. Goto A#*, Okado K#, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL*. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2020 Jan 14;52(1):200.
