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Renjie JIAO

简介

 

焦仁杰教授

广州霍夫曼免疫研究所所长,教授,博士生导师

焦仁杰教授1965130日生于江苏、泰兴。1987年毕业于北京大学生物学系细胞生物学及遗传学专业,获学士学位。1991年获北京大学细胞生物学硕士学位。同年留校任教。历任助教、讲师。1999年获苏黎世大学分子生物学研究所博士学位。2004年受聘于中国科学院生物物理研究所、任课题组长/研究员/PIPrincipal Investigator)。2011年获中国科学院优秀导师称号。2017年受聘于广州医科大学、任教授/PI、研究所所长。现任《Journal of Genetics and Genomics》副主编;英国癌症研究基金会(Cancer Research UK)、奥地利国家自然科学基金(Austrian National Science Foundation)等基金评审人,《Nature Communications》、《Journal of Cell Science》、《Journal of Molecular Cell Biology》等科技期刊论文评阅人。焦仁杰实验室主要研究方向是:细胞增殖、分化及免疫调节机制(以果蝇为模式生物)。他至今已在 Nature Cell Biol., Dev. Cell, Cell Res., Nat. Commun., Cancer Res., Development, Oncogene, J. Neurosci.等专业期刊上发表研究论文七十多篇。

 

课题组研究方向

从模式生物黑腹果蝇转化到哺乳动物和人,研究宿主抵抗感染、-宿主-病原体的互作机制。

 

课题组代表文章

1.    Yan Y., H. Wang, C. Wei, Y. Xiang, X. Liang, C. W. Phanga and R. Jiao.  2019.  HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy.  J. Genet. Genomics, in press

2.    Lo, P.-K., Y.-C. Huang, D. Corcoran, R. Jiao and W.-M. Deng.  2019.  Drosophila chromatin assembly factor 1 p105 and p180 subunits are required for follicle cell proliferation via inhibiting Notch signaling.  J. Cell Sci., in press

3.  Chen, J., N. Xu, C. Wang, P. Huang, H. Huang, Z. Jin, Z. Yu, T. Cai, R. Jiao and R. Xi.  2018.  Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.  Nature Cell Biol., 20(2): 152-161.

4.  Yan, Y., H. Wang, M. Hu, L. Jiang, Y. Wang, P. Liu, X. Liang, J. Liu, C. Li, A. Lindström-Battle, W.-M. Deng and R. Jiao*. 2017. HDAC6 suppresses age-dependent ectopic fat accumulation by Maintaining the proteostasis of PLIN2 in Drosophila.  Dev. Cell., 43: 99–111.

5.    Xie, G., H. Chen, D. Jia, Z. Shu, W. Palmer, X. Zeng, S. Hou, R. Jiao* and W.-M. Deng*, 2017. The SWI/SNF complex protein Snr1 is a tumor suppressor in Drosophila imaginal tissues. Cancer Res., 77: 862-873.

6.    Peng, Q., Y. Wang, M. Li, D. Yuan, M. Xu, C. Li, Z. Gong, R. Jiao* and L. Liu*.  2016. cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.  J. Neurosci.  36: 4635 - 4646.

7.    Zhang, H.#, C. Li#, H. Chen, H. Wu, W. Dui, F. Dai, W.-M. Deng* and R. Jiao*.  2015. SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila.  Cell Res., 25: 93-109.

8.    Xie, G., Z. Yu, D. Jia, R. Jiao* and W.-M. Deng*.  2014. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.   J. Cell Sci., 127: 3830 – 3839.

9.    Yu, Z., H. Wu, H. Chen, R. Wang, X. Liang, J. Liu, C. Li, W.-M. Deng* and R. Jiao*. 2013. CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development.  Development, 140: 3635-3644.

10.  Yu, Z., M. Ren, Z. Wang, B. Zhang, Y.S. Rong, R. Jiao* and G. Gao*. 2013. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila.  Genetics, 195: 289-291.

11.  Dui, W., B. Wei, F. He, W. Lu, C. Li, X. Liang, J. Ma* and R. Jiao*.  2013.  The Drosophila F-box protein dSkp2 regulates cell proliferation through targeting Dacapo for degradation.  Mol. Biol. Cell, 24: 1676-1687.

 

课题组成员

1)    副教授

刘继勇

 

2)    助理研究员

邓自豪

 

3)    博士后(Post-doc

焦仁杰教授的博士后(Post-doc of Prof.Jiao

魏传贤、Phang Chungweng

 

4)    科研助理(Research assistant

苗晓莉(Xiaoli Miao

 

5)    技术员

陈泳儒

 

6)    学生

焦仁杰教授的博士

苏方(2017级)龚尚于(2018级)黄婉莹(2019级)

                         

焦仁杰教授的硕士生

黄婉莹(2016级)邓柱(2017级)谢欣雨(2017级)杨艳阳(2018级)张钦豪(2018级)张碧玲(2019级)金灏岚(2019级)张媱(2019级)

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