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Tao PENG

简介

彭涛教授

彭涛教授是中法霍夫曼免疫研究所教授,博士生导师,呼吸疾病国家重点实验室研究员。美国宾夕法尼亚大学病毒学博士。曾任中科院广州生物医药与健康研究院病毒免疫研究室主任,研究员;中国科技大学博士生导师、中国科学院大学博士生导师。2008年入选中科院“百人计划”、 “广州市创新创业领军人才百人计划”。专长:病毒免疫逃逸机制和入侵机制,抗病毒药物以及病毒快速诊断方法等研究。

 

课题组研究方向

我们利用哺乳动物及果蝇研究平台鉴定参与抗病毒反应的保守的宿主因子。我们的研究目标是:(i)寻找并鉴定在果蝇及哺乳动物系统中参与抗病毒反应的保守的宿主因子;(ii) 基于对病毒宿主相互作用的深入研究建立抗病毒活性评价系统发掘更多的抗病毒药物靶点。

 

课题组代表文章

1. Longbo Hu, Jinqian Lib, Hua Cai, Wenxia Yao, Jing Xiao, Yi-Ping Li, Xiu Qiu, Huimin Xia, Tao Peng. Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles. Antiviral Res. 2017, 148:5-14

2. Ting Li, Libao Liu, Hongling Wu, Shaodan Chen, Qinchang Zhu, Hao Gao, Xiongtao Yu, Yi Wang, Wenhan Su, Xinsheng Yao, Tao Peng. Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb. Antiviral Res. 2017, 144:273-280

3. Xu Y, Ma S, Zhu L, Huang Z, Chen L, Xu Y, Yin H, Peng T, Wang Y. Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model. Antiviral Res. 2017, 137:67-75.

4. Cai H, Yao W, Li L, Li X, Hu L, Mai R, Peng T. Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Sci Rep. 2016, 10;6:27778.

5. Zhang C, Wang Y, Ma S, Li L, Chen L, Yan H, Peng T. Human Enterovirus 71 Protein Displayed on the Surface of Saccharomyces cerevisiae as an Oral Vaccine. Viral Immunol. 2016, 29(5):288-95.

6. Wang F, Li Z, Li L, Hu L, Xiao J, Su Z, Peng T. GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation. Cell Biol Int. 2015, 39(3):334-40

7. Wenxia Yao, Hua Cai, Xinlei Li, Ting Li, Longbo Hu, Tao Peng. Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1. Journal of Virology. 2014, 88(15):8361-8374.

8. Xinlei Li, Hanfang Jiang, Linbing Qu, Wenxia Yao, Hua Cai, Ling Chen, Tao Peng Hepatocyte Nuclear Factor-4 Alpha (HNF4α) and Downstream Secreted Phospholipase A2 GXIIB (PLA2GXIIB) Regulate Production of Infectious Hepatitis C Virus. Journal of Virology. 2014, 88(1):612-27.

9. Longbo Hu, Wenxia Yao, Fang Wang, Xia Rong, Tao Peng. GP73 Is Upregulated by Hepatitis C Virus (HCV) Infection and Enhances HCV Secretion. PLoS One. 2014, 9(3): e90553.

10. Ting Li, Tao Peng. Traditional Chinese Herbal Medicine as a source of molecules with antiviral activity. Antiviral Research. 2013, 97(1):1-9.

 

课题组成员

1)    副教授、副研究员

陈笛、龙飞

 

2)    助理研究员

胡龙波、李新磊、蔡华

 

3)    科研助理

吴丽平、肖静

 

4)    学生

彭涛教授的博士:

夏淑(2014级)马书智(2015级)许煜华(2016级)杜莹莹(2017级)李璐(2018级)

 

彭涛教授的硕士生:

区显途(2014级)朱丽蒙(2014级)麦润明(2015级)黄劲贤(2016级)黄洁卿(2016级)郭欣瑜(2017级) 张玮炜(2017级)梁梦迪(2018级)赵祥(2018级)方健民(2019级)梅玲玲(2019级)

 

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