简介

陈笛副教授

陈笛，广州医科大学广州霍夫曼免疫研究所副研究员。2008年硕士毕业于暨南大学，专业为免疫学。2014年博士毕业于加拿大西安大略大学，课题方向为体内siRNA的特异转运以实现RNAi的靶向疗法，主要集中在靶向DC的肿瘤免疫疗法。曾经获得加拿大健康研究院年度学术海报陈述金奖，西安大略大学病理系以及肿瘤系年度学术日海报最佳陈述奖。目前获得中国国家留学奖学金资助，在朱尔斯.霍夫曼教授实验室深造，研究方向为以果蝇为模型探索天然免疫对原癌细胞的识别以及反应机制。

       Di Chen, Associate professor of Sino-French Hoffmann Institute of Guangzhou Medical University. She majored in immunology and graduated her master degree from JiNan University with the first class scholarship in 2008. In 2013, she graduated her Ph.D. in Western University (was named University of Western Ontario) in Canada. Her topic was targeted siRNA delivery for RNAi therapy. She was mainly focused on DC targeting siRNA delivery for cancer immune therapy. During her Ph.D., she won the gold medal of Canada institution of health research (CIHR) annual poster competition. She also won the best poster presentation award in the annual research day of oncology and pathology department of Western University. After that, she joined SFHI in the group of Professor Tao Peng in 2014. Now she is supported by a national Chinese scholarship and continues her training in Prof. Jules Hoffmann’s laboratory. Now her research interest is using Drosophila as a model to study the recognition and response of innate immunity again oncogenic cells.

课题组研究方向

以果蝇成虫为模型探索天然免疫对原癌细胞的反应机制。

Innate immune response against oncogenic cells in adult Drosophila.

代表文章

1. D Chen(#), J Koropatnick , N Jiang, X Zheng, X Zhang, R Li, King S Siu, A Shunnar, C Way and W Min(*). Targeted siRNA silencing of IDO in dendritic cells using mannose-conjugated liposomes: a novel strategy for treatment of melanoma. Journal of immunotherapy, 2014, 37(2):123-34. 

2. King Sun Siu(#), Di Chen, Xiufen Zheng, Xusheng Zhang, Nathan Johnston, Yanling Liu, Ken Yuan, James Koropatnick, Elizabeth R. Gillies and Wei-Ping Min(*). Single-walled carbon nanotubes non-covalently functionalized with lipid modified polyethylenimine for siRNA delivery in vitro and in vivo. Biomaterials, 2014, 35:3435-3442. 

3. Zhou L, Chen D, Huang XM, Long F, Cai H, Yao WX, Chen ZC, Liao ZJ, Deng ZZ, Tan S, Shan YL, Cai W, Wang YG, Yang RH, Jiang N, Peng T, Hong MF, Lu ZQ. Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation. Front Cell Neurosci, 2017,281(11): 1-16. 

4. Cai M, Chen D, Zeng Z, Yang H, Jiang S, Li X, Mai J, Peng T, Li M. Characterization of the nuclear import signal of herpes simplex virus 1 UL31, 2016, 161(9):2379-85. 

5.陈玲(#)，邢飞跃(*), 狄静芳，陈笛，廖继东. Jagged1在树突状细胞介导淋巴细胞诱导免疫耐受中的作用.中华微生物和免疫学杂志，2008, 29 (2): 147-151./p>