简介
Jules Hoffmann教授
Jules Hoffmann教授是出生于卢森堡的法国籍生物学家。他在法国斯特拉斯堡大学获得生物学以及化学博士学位。他于1994年至2006年间在法国国家科学研究中心（CNRS）细胞以及分子生物学研究所内建立并领导内分泌以及昆虫免疫实验室。至今，他与同事仍在此实验室共同工作。他曾任法国国家科学院院长(2007－2008)，并为法国国家科学院、德国国家科学院、俄罗斯国家科学院、美国艺术以及科学院以及美国癌症研究协会院士。2011年，由于他对于天然免疫激活机制的重要发现，与Bruce Beutler教授以及Ralph Steinman教授共同获得诺贝尔生理学或医学奖。Hoffmann教授于2004年获得罗伯特•科赫免疫学奖（Robert Koch Prize 2004），2007年与Bruce Beutler教授共获巴尔赞天然免疫学奖(Balzan Prize 2007)，2010年与Ruslan Medzhitov教授共获罗森斯蒂尔奖(Rosenstiel Award 2010), 2011年与静雄アキラ教授共同获得庆应义塾医学科学奖(Gairdner Award 2011), 2011获与Bruce Beutler教授and Ruslan Medzhitov教授得肖生命科学以及医学奖(Shaw Prize 2011)。并且他于2011年获得享有盛誉的法国国家科学院金奖(CNRS Gold Medal 2011)。此外，Jules Hoffmann教授还是法兰西荣誉军团军官和法兰西学院的“不朽者”(法兰西学院院士)。
目前，霍夫曼教授是广州医科大学广州霍夫曼免疫研究所的名誉所长以及科学委员会主席。从2018学年度开始正式招收博士研究生。欢迎具有分子生物学、细胞生物学以及免疫学教育背景的学生申报。表现优异者，可以申请斯特拉斯堡与广州医科大学双博士学位。
具体请联系：广州医科大学博士生报名系统：http://210.38.57.153/phd/
招生简章：http://210.38.57.78:8019/pub/yjsjy/jqjd/14997.htm
或陈笛：chenseptember@outlook.com
Jules Hoffmann, Nobel laureate of 2011 Physiology or Medicine
代表文章
1) J.A. HOFFMANN (1970). Les organes hématopoiétiques de deux Insectes Orthoptères : Locusta migratoria et Gryllus bimaculatus. Z. Zellforsch. Vol 106 451-472
2) J.A. HOFFMANN (1973). Blood-forming tissues in Orthopteran Insects : an analogue to Vertebrate hemopoietic organs. Experientia. Vol 29 50-51
3) J.A. HOFFMANN, J. KOOLMAN, P. KARLSON & P. JOLY (1974). Molting hormone titer and metabolic fate of injected ecdysone during the fifth larval instar and in adults of Locusta migratoria. Gen. Compar. Endocri. Vol 22 90-97
4) P. KARLSON, J. KOOLMAN & J.A. HOFFMANN (1975). Biochemistry of ecdysone. Amer. Zool. Vol 15 49-59
5) G. TSOUPRAS, B. LUU & J.A. HOFFMANN (1982). Isolation and identification of three ecdysteroid conjugates with a C-20 hydroxy group in eggs of Locusta migratoria. Steroids. Vol 40 551-560
6) M.F. Costet, M. El Achouri, M. Charlet, R. Lanot, P. Benveniste & J.A. Hoffmann (1987). Ecdysteroid biosynthesis and embryonic development are disturbed in insects (Locusta migratoria) reared on plant diet (Triticum sativum) with a selectively modified sterol profile. Proc. Nat. Acad. Sci. Vol 84 643-647
7) J. Lambert, E. Keppi, J.L. Dimarcq, C. Wicker, J.M. Reichhart, B. Dunbar, P. Lepage, A. Van Dorsselaer, J.A. Hoffmann, J. Fothergill & D. Hoffmann (1989). Insect immunity. Isolation from immune blood of the Dipteran Phormia terranovae of two novel antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides. Proc. Nat. Acad. Sci. Vol 86 262-266
8) M. LAGUEUX, L. LWOFF, M. MEISTER, F. GOLTZENé & J.A. HOFFMANN (1990). cDNAs from neurosecretory cells of brains of Locusta migratoria (Insecta, Orthoptera) encoding a novel member of the superfamily of insulins. Eur. J. Biochem. Vol 187 249-254
9) J.A. HOFFMANN & D. HOFFMANN (1990). The inducible antibacterial peptides of dipteran insects. Res. Immunol. Vol 141 910-918
10) DIMARCQ JL, HOFFMANN D, MEISTER M, BULET P, LANOT R, REICHHART JM & HOFFMANN JA (1994). Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity. Eur. J. Biochem. Vol 221 201-209
11) LEMAITRE B, KROMER-METZGER E, MICHAUT L, NICOLAS E, MEISTER M, GEORGEL P, REICHHART JM & HOFFMANN JA (1995). A recessive mutation, immune-deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. Vol 92 9465-9469
12) FRANC N, DIMARCQ JL, LAGUEUX M, HOFFMANN JA & EZEKOWITZ A (1996). Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. Vol 4 431-443
13) LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM & HOFFMANN JA (1996). The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in Drosophila adults. Cell. Vol 86 973-983
14) FERRANDON D, JUNG AC, CRIQUI MC, LEMAITRE B, UTTENWEILER-JOSEPH S, MICHAUT L, REICHHART JM & HOFFMANN JA (1998). A GFP-drosomycin reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J. Vol 17 1217-1227
15) DIMARCQ JL, BULET P, HETRU C & HOFFMANN JA (1998). Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers (Peptide Science). Vol 47 465-477
16) HOFFMANN JA, KAFATOS FC, JANEWAY CA JR & EZEKOWITZ RAB (1999). Phylogenetic perspectives in innate immunity. Science. Vol 284 1313-1318
17) RUTSCHMANN S, JUNG AC, ZHOU R, SILVERMAN N, HOFFMANN JA & FERRANDON D (2000). Role of Drosophila IKK in a Toll-independent antibacterial immune response. Nature Immunol. Vol 1 342-347
18) TZOU P, OHRESSER S, FERRANDON D, CAPOVILLA M, REICHHART JM, LEMAITRE B, HOFFMANN JA & IMLER JL (2000). Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. Vol 13 737-748
19) GEORGEL, P., NAITZA S., KAPPLER, C., FERRANDON, D., ZACHARY, D., SWIMMER, C., KOPCZYNSKI, C., DUYK, G., REICHHART, J-M., AND HOFFMANN, J.A. ( 2001). Drosophila Immune Deficiency (IMD) is a Death Domain Protein that Activates Antibacterial Defence and Can Promote Apoptosis. Developmental Cell. Vol 1, 1-20, 503-514
20) MICHEL T, REICHHART JM, HOFFMANN JA & ROYET J. (2001). Drosophila Toll is activated by Gram-positive bacteria via a circulating peptidoglycan recognition protein. Nature. Vol 414, 756-759
21) GOTTAR M, GOBERT V, MICHEL T, BELVIN M, DUYK G, HOFFMANN JA, FERRANDON D, ROYET J, (2002). The Drosophila immune response against Gram-negative bacteria is médiated by a peptidoglycan recognition protein, Nature. Vol 416, 641-644
22) LIGOXYGAKIS P, PELTE N, HOFFMANN JA, REICHHART JM, (2002), Activation of Drosophila Toll during fungal infection by a novel blood serine protease, Science. Vol 297, 114-116
23) DOSTERT C, JOUANGUY E, IRVING P, TROXLER L, GALIANA-ARNOUX D, HETRU C, HOFFMANN JA, IMLER JL (2005). The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila. Nature Immunol. Vol 6, 946-953.
24) FROLET C, THOMA M, BLANDIN S, HOFFMANN JA, LEVASHINA EA (2006). Boosting NF-kB Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei. Immunity. Vol 25, 677-685.
25) BEUTLER B, EIDENSCHENK C, CROZAT K, IMLER JL, TAKEUCHI O, HOFFMANN JA, AKIRA S (2007). Genetic analysis of resistance to viral infection. Nature Reviews of Immunology. Vol 7, 753-766.
26) FERRANDON D, IMLER JL, HETRU C, HOFFMANN JA (2007). The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nature Reviews of Immunology. Vol 7, 862-874.
27) LEMAITRE B, HOFFMANN JA (2007). The host defense of Drosophila melanogaster. Annual Review of Immunology. Vol 25, 697-743.
28) HOFFMANN JA (2007). Antifungal defense in Drosophila. Nature Immunology. Vol 8, 543-545.
29) DEDDOUCHE S, MATT N, BUDD A, MUELLER S, KEMP C, GALIANA-ARNOUX D, DOSTERT C, ANTONIEWSKI C, HOFFMANN JA, IMLER JL (2008). The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in Drosophila. Nature Immunology. Vol 9, 1425-1432.
30) FRAITURE M, BAXTER RH, STEINERT S, CHELLIAH Y, FROLET C, QUISPE-TINTAYA W, HOFFMANN JA, BLANDIN SA, LEVASHINA EA (2009). Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host Microbe. Vol 5, 273-84.
