沈二霞，女，副教授 ，硕导。

研究方向：免疫应答、炎症疾病和肿瘤免疫。

受教育和工作经历： 2017至今，广州医科大学，基础学院，副教授 2014-2017，哈佛大学，博士后，导师：Harvey Cantor（美国科学院院士、艺术与人文学院院士） 2009-2014，广州医科大学，基础学院，讲师/副教授 2004-2009，中山大学，硕博连读，免疫学博士，导师：吴长有

科研项目主持国家自然科学基金、省市厅级等各类项目十余项，目前在研经费40多万元。

学术成果 1.阐明了转录因子Blimp1通过调控IL-2R-pSTAT5和IL-23R-pSTAT3轴调控Tfr发育分化和维持。 2. 阐明了骨桥蛋白通过作为桥连接蛋白，促进Bcl6-NuRD复合体的形成，进而同NURD复合体介导的表观遗传学调控Tfr和Tfh的早期分化发育。该部分以第一作者发表在PNAS上 （影响因子9.6）。 3. 发现了在白血病AML中存在一群功能失调的CD8+T细胞，其表型为PD-1+TIGIT+CD226-。该群细胞与AML的临床预后呈相关性。发表SCI论文10余篇，总计影响因子40多分。

主要著作和论文 https://www.ncbi.nlm.nih.gov/pubmed/?term=erxia+shen[au] 1.Erxia Shen (#), Qin Wang (#), Hardis Rabe, Wenquan Liu, Harvey Cantor(通讯), and Jianmei W. Leavenworth(通讯). Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells. PNAS June 11, 2018. 201805239; published ahead of print June 11, 2018. https://doi.org/10.1073/pnas.1805239115 (IF=9.66) 2.Wang M, Bu J, Zhou M, Sido J, Lin Y, Liu G, Lin Q, Xu X, Leavenworth JW, Shen E. CD8+T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in Acute Myeloid Leukemia (AML) patients. Clin Immunol. 2017 Sep 8. pii: S1521-6616(17)30424-2. doi: 10.1016/j.clim.2017.08.021. 3.Erxia Shen, Mengjie Wang, Hairui Xie, Ruqiong Zou, Qiwen Lin, Lili lai, Fujun Li, Zhimei Liang, Yanran Xu, and Maohua Zhou. Existence of Th22 in children and evaluation of IL-22 + CD4 + T, Th17, and other T cell effector subsets from healthy children compared to adults. BMC Immunol. 2016 Jun 23;17(1):20. doi: 10.1186/s12865-016-0158-8. 4.Leavenworth JW, Verbinnen B, Wang Q, Shen E, Cantor H(通讯). Intracellular osteopontin regulates homeostasis and function of natural killer cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):494-9. 5.Zhou M, Zou R, Gan H, Liang Z, Li F, Lin T, Luo Y, Cai X, He F, Shen E (通讯).The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects. Immun Ageing. 2014 Aug 23;11:12 6.Erxia Shen, Baoxin Yang, Yang Li, Qiwen Lin, Ruoqiong Zou, Huayi Huang, Jie Wu, Shuxia Zhang, Juntao Zou, Maohua Zhou(通讯), Yaping Tang(通讯). CSA INHIBITS IL-22 PRODUCTION BY MEMORY CD4+T CELLS FROM PATIENTS WITH PSORIASIS. ARCHIVES OF BIOLOGICAL SCIENCES. 2014;66 (2), 775-784. 7.Zhao K, Zhao D, Huang D, Yin L, Chen C, Pan B, Wu Q, Li Z, Yao Y, Shen E, Zeng L, Xu K(通讯). Interleukin-22 aggravates murine acute graft-versus-host disease by expanding effector T cell and reducing regulatory T cell. J Interferon Cytokine Res. 2014 Sep;34(9):707-15. 8.Liu H(#), Luo X(#), Shen E, Li H, Ding X, Chen D(通讯). Alteration of T cell subtypes in spleen and antibodies of serum in mice infected with Angiostrongylus cantonensis. Parasitol Res. 2013 Mar;112(3):1255-60. 9.Shen E, Zhao K, Wu C, Yang B(通讯). The suppressive effect of CD25+Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-β production. Cell Biol Int. 2011;35(7), 705–712. 10.Shen E, Lu L, Wu C. TLR7/8 ligand, R-848, inhibits IgE synthesis by acting directly on B lymphocytes. Scand J Immunol. 2008; 67(6):560-568. 11.Shen E, Li L, Li L, Feng L, Lu L, Yao Z, Lin H, Wu C. PIKA as an adjuvant enhances specific humoral and cellular immune responses following the vaccination of mice with HBsAg plus PIKA. Cell Mol Immunol. 2007; 4(2):113-120. （IF=7.5）

联系方式：erxia_shen@yahoo.com

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