个人简介
Jules Hoffmann教授
Jules Hoffmann教授是2011年诺贝尔生理学或医学奖的得主，目前是斯特拉斯堡大学的终身教授，广州医科大学霍夫曼免疫研究所名誉所长以及特聘教授，法国科学院以及法兰西学院的两院院士，德国国家科学院、俄罗斯国家科学院以及美国癌症研究协会院士。2013年Jules Hoffmann教授与广州医科大学合作签订协议，建立霍夫曼免疫研究所（sino-French Hoffmann Institute），2019年10月Hoffmann教授联合陈笛副研究员以及Akira Goto(法国国家健康与医学研究中心副教授，终身职位，广州医科大学特聘教授)在霍夫曼免疫研究所设立以果蝇为模型的天然免疫抗肿瘤机制研究课题组，目前课题经费充足。研究所以昆虫为模型研究天然免疫机制相关的分子以及遗传机制。（网站https://sfhi.gzhmu.edu.cn/Hoffmann）2011年，由于他对于天然免疫激活机制的重要发现，与Bruce Beutler教授以及Ralph Steinman教授共同获得诺贝尔生理学或医学奖。此外，Jules Hoffmann教授还是法兰西荣誉军团军官和法兰西学院的“不朽者”(法兰西学院院士)。他及其同事的研究开启了人们对天然免疫在哺乳动物中的重要作用有了重新的认识。
目前，霍夫曼教授是广州医科大学广州霍夫曼免疫研究所的名誉所长以及科学委员会主席。从2018学年度开始正式招收博士研究生。欢迎具有分子生物学、细胞生物学以及免疫学教育背景的学生申报。表现优异者，可以申请斯特拉斯堡与广州医科大学双博士学位。
具体请联系：
广州医科大学博士生报名系统：http://210.38.57.153/phd/
招生简章：http://210.38.57.78:8019/pub/yjsjy/jqjd/14997.htm
或陈笛：chenseptember@outlook.com
Jules Hoffmann, Nobel laureate of 2011 Physiology or Medicine
代表文章：
1. Di Chen *, Xiao Lan , Xiaoming Huang , Jieqing Huang , Xiaojing Zhou , Jiyong Liu , Jules A Hoffmann*. Methuselah like 1, a Drosophila homologue of Mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies. PNAS, 2023, (in press).
2. Di Chen*, Xiao Lan, Xiaoming Huang, Jieqing Huang, Xiaojing Zhou, Zhichao Miao, Yuting Ma, Akira Goto, Shanming Ji, Jules A. Hoffmann*. Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila. Journal of Innate Immunity, 2023, 15:442–467.
3. Di Chen (#)*, Arghyashree Roychowdhury-Sinha, Pragya Prakash, Xiao Lan, Wenmin Fan, Akira Goto*, Jules A. Hoffmann*. A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defences. PNAS, 2021, 118.
4. Goto A#*, Okado K#, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL*. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2020 Jan 14;52(1):200.
5. FRAITURE M, BAXTER RH, STEINERT S, CHELLIAH Y, FROLET C, QUISPE-TINTAYA W, HOFFMANN JA, BLANDIN SA, LEVASHINA EA (2009). Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host Microbe. Vol 5, 273-84.
6. DEDDOUCHE S, MATT N, BUDD A, MUELLER S, KEMP C, GALIANA-ARNOUX D, DOSTERT C, ANTONIEWSKI C, HOFFMANN JA, IMLER JL (2008). The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in Drosophila. Nature Immunology. Vol 9, 1425-1432.
7. HOFFMANN JA (2007). Antifungal defense in Drosophila. Nature Immunology. Vol 8, 543-545.
8. LEMAITRE B, HOFFMANN JA (2007). The host defense of Drosophila melanogaster. Annual Review of Immunology. Vol 25, 697-743.
9. FERRANDON D, IMLER JL, HETRU C, HOFFMANN JA (2007). The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nature Reviews of Immunology. Vol 7, 862-874.
10. BEUTLER B, EIDENSCHENK C, CROZAT K, IMLER JL, TAKEUCHI O, HOFFMANN JA, AKIRA S (2007). Genetic analysis of resistance to viral infection. Nature Reviews of Immunology. Vol 7, 753-766.
11. FROLET C, THOMA M, BLANDIN S, HOFFMANN JA, LEVASHINA EA (2006). Boosting NF-kB Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei. Immunity. Vol 25, 677-685.
12. DOSTERT C, JOUANGUY E, IRVING P, TROXLER L, GALIANA-ARNOUX D, HETRU C, HOFFMANN JA, IMLER JL (2005). The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila. Nature Immunol. Vol 6, 946-953.
13. LIGOXYGAKIS P, PELTE N, HOFFMANN JA, REICHHART JM, (2002), Activation of Drosophila Toll during fungal infection by a novel blood serine protease, Science. Vol 297, 114-116
14. GOTTAR M, GOBERT V, MICHEL T, BELVIN M, DUYK G, HOFFMANN JA, FERRANDON D, ROYET J, (2002). The Drosophila immune response against Gram-negative bacteria is médiated by a peptidoglycan recognition protein, Nature. Vol 416, 641-644
15. MICHEL T, REICHHART JM, HOFFMANN JA & ROYET J. (2001). Drosophila Toll is activated by Gram-positive bacteria via a circulating peptidoglycan recognition protein. Nature. Vol 414, 756-759
16. GEORGEL, P., NAITZA S., KAPPLER, C., FERRANDON, D., ZACHARY, D., SWIMMER, C., KOPCZYNSKI, C., DUYK, G., REICHHART, J-M., AND HOFFMANN, J.A. ( 2001). Drosophila Immune Deficiency (IMD) is a Death Domain Protein that Activates Antibacterial Defence and Can Promote Apoptosis. Developmental Cell. Vol 1, 1-20, 503-514
17. TZOU P, OHRESSER S, FERRANDON D, CAPOVILLA M, REICHHART JM, LEMAITRE B, HOFFMANN JA & IMLER JL (2000). Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. Vol 13 737-748
18. RUTSCHMANN S, JUNG AC, ZHOU R, SILVERMAN N, HOFFMANN JA & FERRANDON D (2000). Role of Drosophila IKKg in a Toll-independent antibacterial immune response. Nature Immunol. Vol 1 342-347
19. HOFFMANN JA, KAFATOS FC, JANEWAY CA JR & EZEKOWITZ RAB (1999). Phylogenetic perspectives in innate immunity. Science. Vol 284 1313-1318
20. DIMARCQ JL, BULET P, HETRU C & HOFFMANN JA (1998). Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers (Peptide Science). Vol 47 465-477
21. FERRANDON D, JUNG AC, CRIQUI MC, LEMAITRE B, UTTENWEILER-JOSEPH S, MICHAUT L, REICHHART JM & HOFFMANN JA (1998). A GFP-drosomycin reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J. Vol 17 1217-1227
22. LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM & HOFFMANN JA (1996). The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in Drosophila adults. Cell. Vol 86 973-983
23. FRANC N, DIMARCQ JL, LAGUEUX M, HOFFMANN JA & EZEKOWITZ A (1996). Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. Vol 4 431-443
24. LEMAITRE B, KROMER-METZGER E, MICHAUT L, NICOLAS E, MEISTER M, GEORGEL P, REICHHART JM & HOFFMANN JA (1995). A recessive mutation, immune-deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. Vol 92 9465-9469
25. DIMARCQ JL, HOFFMANN D, MEISTER M, BULET P, LANOT R, REICHHART JM & HOFFMANN JA (1994). Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity. Eur. J. Biochem. Vol 221 201-209
26. J.A. HOFFMANN & D. HOFFMANN (1990). The inducible antibacterial peptides of dipteran insects. Res. Immunol. Vol 141 910-918
27. M. LAGUEUX, L. LWOFF, M. MEISTER, F. GOLTZENÉ & J.A. HOFFMANN (1990). cDNAs from neurosecretory cells of brains of Locusta migratoria (Insecta, Orthoptera) encoding a novel member of the superfamily of insulins. Eur. J. Biochem. Vol 187 249-254
28. J. LAMBERT, E. KEPPI, J.L. DIMARCQ, C. WICKER, J.M. REICHHART, B. DUNBAR, P. LEPAGE, A. VAN DORSSELAER, J.A. HOFFMANN, J. FOTHERGILL & D. HOFFMANN (1989). Insect immunity. Isolation from immune blood of the Dipteran Phormia terranovae of two novel antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides. Proc. Nat. Acad. Sci. Vol 86 262-266
29. M.F. COSTET, M. EL ACHOURI, M. CHARLET, R. LANOT, P. BENVENISTE & J.A. HOFFMANN (1987). Ecdysteroid biosynthesis and embryonic development are disturbed in insects (Locusta migratoria) reared on plant diet (Triticum sativum) with a selectively modified sterol profile. Proc. Nat. Acad. Sci. Vol 84 643-647
30. G. TSOUPRAS, B. LUU & J.A. HOFFMANN (1982). Isolation and identification of three ecdysteroid conjugates with a C-20 hydroxy group in eggs of Locusta migratoria. Steroids. Vol 40 51-560
31. P. KARLSON, J. KOOLMAN & J.A. HOFFMANN (1975). Biochemistry of ecdysone. Amer. Zool. Vol 15 49-59
32. J.A. HOFFMANN, J. KOOLMAN, P. KARLSON & P. JOLY (1974). Molting hormone titer and metabolic fate of injected ecdysone during the fifth larval instar and in adults of Locusta migratoria. Gen. Compar. Endocri. Vol 2 90-97
33. J.A. HOFFMANN (1973). Blood-forming tissues in Orthopteran Insects : an analogue to Vertebrate hemopoietic organs. Experientia. Vol 29 50-51
34. J.A. HOFFMANN (1970). Les organes hématopoiétiques de deux Insectes Orthoptères :Locusta migratoria et Gryllus bimaculatus. Z. Zellforsch. Vol 106 451-472
