简介

Akira Goto

        Akira Goto毕业于日本名古屋大学，之后加入法国卫生和医学研所，并于斯特拉斯堡法国国家科学研究中心（CNRS）细胞以及分子生物学研究所终身高级研究员。

他的研究项目主要是利用果蝇（Drosophila melanogaster）这种模式生物揭示先天免疫反应的基本分子机制。果蝇本身是遗传学研究的重要模式生物。更重要的是，果蝇具有与脊椎动物高度保守的信号通路和病原反应机制，并且还兼具非保守的昆虫特异性，使其成为传染性疾病的重要动物模型。 通过阐述先天免疫信号传导途径的分子机制并利用各种筛选技术寻找新分子，他的长期科研目标是贡献于预防、诊断以及治疗感染性疾病以及炎症。目前，以果蝇为模型，他已经成功鉴定出在果蝇天然免疫中具有重要功能的分子(Goto et al, 2003; Goto et al., 2008; Goto et al., 2010; Goto et al., 2018)。

After his graduate studies at Nagoya University in Japan and postdoctoral training in Strasbourg, he joined the INSERM (Institut national de la santé et de la recherche médicale) working at the Institut de Biologie Moléculaire et Cellulaire (IBMC) of Centre national de la recherche scientifique (CNRS) in Strasbourg as a permanent senior scientist (2012).

His research projects mainly focus on understanding fundamental molecular mechanisms of innate immune responses using Drosophila melanogaster as a model system. Because of the powerful genetic tools available and more importantly, the high conservation signaling and pathogenesis mechanisms with vertebrates and non-conserved insect specific strategies, Drosophila has now become a useful model for the study of infectious diseases. By delineating the molecular mechanisms of innate signaling pathways and hunting for novel molecules with various screening techniques, his long-term research goal is to contribute to the development of new approaches to the prevention, diagnosis and treatment of infectious diseases and inflammation. He has already identified a number of critical molecules involved in different aspects of Drosophila innate immune response (Goto et al, 2003; Goto et al., 2008; Goto et al., 2010; Goto et al., 2018).

课题组研究方向

以果蝇成虫为模型探索天然免疫对原癌细胞的反应机制。

Innate immune response against oncogenic cells in adult Drosophila.