个人概况
李美丽，女，博士，教授，博士/硕士研究生导师，博士后合作导师，毕业于中国科学院武汉病毒研究所，现任职于基础医学院广州霍夫曼免疫研究所病原生物学与免疫学教研室。
电子邮件：1035579138@qq.com
研究方向
分子病毒学及病毒免疫学：主要从事疱疹病毒特别是人类肿瘤相关病毒（EB病毒）、I型单纯疱疹病毒（HSV-1）和动物疱疹病毒（PRV）疫苗、药物、感染的天然免疫、编码蛋白的核质转运、蛋白质相互作用分子机理及其生物学功能等的相关研究。
所获荣誉
1. 广东省高等学校优秀青年教师培养对象
2. 广东省“千百十人才培养工程”第八批培养对象
3. 广州市珠江科技新星
4. 广州市高层次人才
5. 广州医科大学“南山学者”人才计划
6. 广州医科大学高水平大学学术骨干培育对象
7. 广州医科大学首批“青年骨干教师培养工程”培养对象
指导学生获得的科研项目和奖项
1. 指导本科生获得国家级、省级、市级和校级等科研项目和全国大学生设计大赛以及“挑战杯”广东大学生课外学术科技作品竞赛奖项50余项。
2. 指导研究生获得研究生国家奖学金、优秀研究生称号、研究生企业奖学金和研究生学业奖学金等多种奖学金及科研立项。
社会兼职
1. 国家自然科学基金评审专家
2. 广东省自然科学基金评审专家
3. 国家科技专家库和教育部科技评价与评审信息系统专家
4. 广东省热带医学学会理事、广东省和湖北省免疫学会会员
5. 多个杂志审稿专家：Journal of Advanced Research、Frontiers in Immunology、Virologica Sinica、Computers in Biology and Medicine、Plos One、Archives of Virology、Journal of Basic Microbiology、F1000Research和Protein & Peptide Letters
主持科研项目
主持国家级（国家自然科学基金）、省级（广东省自然科学基金）、市级（广州市珠江科技新星专项和广州市属高校科研项目）、厅级（广东省医学科研基金）和校级（广州医科大学博士启动项目）等多个级别科研项目，研究经费充足。
部分代表性第一和通讯作者论文：
1) Lan Gong, Xiaowen Ou, Li Hu, Jiayi Zhong, Jingjing Li, Shenyu Deng, Bolin Li, Lingxia Pan, Liding Wang, Xuejun Hong, Wenqi Luo, Qiyuan Zeng, Jie Zan, Tao Peng(*),Mingsheng Cai*,Meili Li*. The molecular mechanism of herpes simplex virus 1 UL31 in antagonizing the activity of IFN-β.Microbiology Spectrum, 2022, 10(1): e01883-21.
2) Jingjing Li, Yingjie Guo, Yangxi Deng, Li Hu, Bolin Li, Shenyu Deng, Jiayi Zhong, Li Xie, Shaoxuan Shi, Xuejun Hong, Xuelong Zheng,Mingsheng Cai*,Meili Li*. Subcellular localization of Epstein-Barr virus BLLF2 and its underlying mechanisms.Frontiers in Microbiology, 2021,12:672192.
3) Ping Wang, Yangxi Deng, Yingjie Guo, Zuo Xu, Yiwen Li, Xiaowen Ou, Li Xie, Manjiao Lu, Jiayi Zhong, Bolin Li, Li Hu, Shenyu Deng, Tao Peng, Mingsheng Cai*,Meili Li*（通讯）. Epstein-Barr virus early protein BFRF1 suppresses IFN-β activity by inhibiting the activation of IRF3.Frontiers in Immunology, 2020, 11:513383.
4) Meili Li, Shuai Wang, Mingsheng Cai, Chunfu Zheng*. Identification of nuclear and nucleolar localization signals of pseudorabies virus (PRV) early protein UL54 reveals that its nuclear targeting is required for efficient production of PRV.Journal of Virology, 2011, 85(19): 10239-10251.
5) Mingsheng Cai, Zongmin Liao, Xingmei Zou, Zuo Xu, Yuanfang Wang, Tong Li, Yiwen Li, Xiaowen Ou, Yangxi Deng, Yingjie Guo, Tao Peng,Meili Li*（通讯）. Herpes simplex virus 1 UL2 inhibits the TNF-α-mediated NF-κB activity by interacting with p65/p50.Frontiers in Immunology, 2020, 11:549.
6) Tao Chen, Yuanfang Wang, Zuo Xu, Xingmei Zou, Ping Wang, Xiaowen Ou, Yiwen Li, Tao Peng, Daixiong Chen,Meili Li*（通讯）, Mingsheng Cai*. Epstein-Barr virus tegument protein BGLF2 inhibits NF-kB activity by preventing p65 Ser536 phosphorylation.FASEB Journal, 2019, 33(9):10563-10576.
7) Meili Li, Zongmin Liao, Zuo Xu, Xingmei Zou, Yuanfang Wang, Hao Peng, Yiwen Li, Xiaowen Ou, Yangxi Deng, Yingjie Guo, Weidong Gan, Tao Peng, Daixiong Chen, Mingsheng Cai*. The interaction mechanism between herpes simplex virus 1 glycoprotein D and host antiviral protein viperin.Frontiers in Immunology, 2019, 10: 2810.
8) Meili Li, Xingmei Zou, Yuanfang Wang, Zuo Xu, Xiaowen Ou, Yiwen Li, Delong Liu, Yingjie Guo, Yangxi Deng, Si Jiang, Tong Li, Shaoxuan Shi, Yilong Bao, Tao Peng, Mingsheng Cai*（通讯）. The nuclear localization signal-mediated nuclear targeting of herpes simplex virus 1 early protein UL2 is important for efficient viral production.Aging-US, 2020, 12(3): 2921-2938.
9) Mingsheng Cai, Si Jiang, Zhancheng Zeng, Xiaowei Li, Chuncong Mo, Yanjia Yang, Chunke Chen, Peiping Xie, Yun Bian, Jinlin Wang, Jinlu Huang, Daixiong Chen, Tao Peng,Meili Li（通讯）*. Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22.Cell & Bioscience, 2016, 6: 3.
10) Mingsheng Cai, Ping Wang, Yuanfang Wang, Tao Chen, Zuo Xu, Xingmei Zou, Xiaowen Ou, Yiwen Li, Daixiong Chen, Tao Peng,Meili Li（通讯）*. Identification of the molecular determinants for nuclear import of PRV EP0.Biological Chemistry, 2019, 400(10):1385-1394.
11) Mingsheng Cai, Shuxuan Deng,Meili Li*（通讯）. Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes.Vaccine, 2013, 31(9): 1353-1356.
12) Mingsheng Cai, Zebin Huang, Zongmin Liao, Tao Chen, Ping Wang, Si Jiang, Daixiong Chen, Tao Peng, Yun Bian, Gengde Hong, Hang Yang, Zhancheng Zeng, Xiaowei Li,Meili Li*. Characterization of the subcellular localization and nuclear import molecular mechanisms of herpes simplex virus 1 UL2.Biological Chemistry, 2017, 398(4): 509-517.
13) Meili Li, Shuai Wang, Mingsheng Cai, Hong Guo, Chunfu Zheng*. Characterization of molecular determinants for nucleocytoplasmic shuttling of PRV UL54.Virology, 2011, 417(2): 385-393.
14) Mingsheng Cai#,Meili Li#, Chunfu Zheng*. Herpesviral infection and Toll-like receptor 2.Protein & Cell, 2012, 3(8): 590-601.
15) Mingsheng Cai, Si Jiang, Xiaowei Li, Zhancheng Zeng,Meili Li*（通讯）. Characterization of the nuclear import mechanisms of HSV-1 UL31,Biological Chemistry, 2016, 397(6):555-561.
16) Meili Li, Si Jiang, Chuncong Mo, Zhancheng Zeng, Xiaowei Li, Chunke Chen, Yanjia Yang, Jinlin Wang, Jinlu Huang, Daixiong Chen, Tao Peng, Mingsheng Cai*. Identification of molecular determinants for the nuclear import of pseudorabies virus UL31.Archives of Biochemistry and Biophysics, 2015, 587:12-17.
17) Mingsheng Cai, Daixiong Chen, Zhancheng Zeng, Hang Yang, Si Jiang, Xiaowei Li, Jingying Mai, Tao Peng,Meili Li*（通讯）. Characterization of the nuclear import signal of herpes simplex virus 1 UL31.Archives of Virology, 2016, 161(9): 2379-2385.
18) Mingsheng Cai, Zhiyao Zhao, Wei Cui, Lin Yang, Junyi Zhu, Yalan Chen, Changling Ma, Zhuqing Yuan,Meili Li*（通讯）. Molecular properties of the Epstein-Barr virus BFRF3 gene.Virologica Sinica, 2013, 28(6): 368-372.
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