简介
李孜教授
李孜自1998年从南开大学七年制临床医学专业毕业、获得硕士学位后，即到广州医科大学工作。于2004年毕业于中山大学病原生物学专业，获得博士学位。2009年-2011年在美国博士后工作期间，分别在美国新墨西哥大学生物系从事曼氏血吸虫感染与宿主免疫研究、Lovelace呼吸病研究所从事肺癌转移分子机制研究，2013.10-12在法国斯特拉斯堡大学做访问学者期间开始接触果蝇领域。她主要从事于组织型转谷氨酰胺酶、NLRP3炎症小体活化与肝纤维化、肺癌转移及其他炎症性疾病的关系机制研究。现在，她是Dominique Ferrandon教授的Co-PI，负责将模式生物果蝇中发现的宿主-病原体互作机制研究转化到哺乳动物和人。
作为项目主持人获得了国家自然科学基金、省自然科学基金、广州市科技计划、呼吸病国家重点实验室开放课题、自主项目的支持，作为主要参与人参与了学校创新团队项目以及广东省高水平大学项目（免疫学）。已经发表SCI文章多篇：例如，以通讯作者在Front Immunol、Mediators Inflamm、 Parasites & vectors，第一作者在J Biol Chem等杂志上发表学术论文。
Zi Li got her master and bachelor degree in clinical medicine (Seven-year program) at Nan Kai University in 1998 and defended her Ph.D. on the biology of pathogens at Sun Yat-Sen University in 2004. She got a postdoctoral position to work on Schistosoma mansoni infections in Prof. ERIC SAMUEL LOKER’s laboratory at the University of New Mexico and then in Prof. Yong Lin’s laboratory at Lovelace respiratory research institute, Albuquerque, New Mexico, to study the mechanisms of lung cancer metastasis during 2009-2011. She started her Drosophila-related research since her visiting Strasbourg university in Oct-Dec of 2013. She has been focusing on how tissue transglutaminase, NLRP3 inflammasome activation are involved in liver fibrosis, lung cancer metastasis, and other inflammatory diseases. At present, she is working as a co-PI of Prof Ferrandon to investigate host defense against infections and the mechanisms of host-pathogen interactions in mammals, building up on the studies performed on the Drosophila melanogaster model.
As PI, she has been granted by National Natural Science Foundation of China, Provincial Natural Science Foundation of Guangdong, ect. As corresponding author, or 1st author, her group has published many articles in Front Immunol、Mediators Inflamm、 Parasites & vectors, or in J Biol Chem.
主要研究方向（Research interests）
组织型转谷氨酰胺酶、NLRP3炎症小体活化与呼吸系统疾病的关系及其机制；模式生物黑腹果蝇转化到哺乳动物和人，研究宿主抵抗感染、-宿主-病原体的互作机制。
Focus on whether and how tissue transglutaminase, NLRP3 inflammasome activation are involved in respiratory diseases; Study on host defense against infections and mechanisms of host-pathogen interactions in the genetic model organism Drosophila melanogaster and in mammalian
代表性论文（Selected publications）
1) Wen Z, Ji X, Tang J, Lin G, Xiao L, Liang C, Wang M, Su F, Ferrandon D, Li Z李孜. Positive Feedback Regulation between Transglutaminase 2 and Toll-Like Receptor 4 Signaling in Hepatic Stellate Cells Correlates with Liver Fibrosis Post Schistosoma japonicum Infection. Front Immunol. 2017 Dec 13;8:1808.
2) Li Z, Xu X, Bai L, Chen W, Lin Y. EGFR-mediated tTG overexpression couples acquired TRAIL-resistance and migration involving c-FLIP and MMP9 in NSCLC cells. J Biol Chem. 2011 Jun 17;286(24):21164-72.
3) Li ZY, Xiao L, Lin G, Tang J, Chen Y, Chen L, Li B, Wu M, Liu S, Huang C, Ferrandon D, Li Z.Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression.Parasit Vectors. 2019 Jun 14;12(1):302. doi: 10.1186/s13071-019-3542-4.
4) Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, Liégeois S, Ferrandon D*. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. EMBO Rep. 2018 Mar 9. pii: e44880.
5) Tang J, Zhu X, Zhao J, Fung M, Li Y, Gao Z, Yan S, Li X, Ji X, Su F, Li Z. Tissue Transglutaminase-Regulated Transformed Growth Factor-β1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis. Mediators Inflamm. 2015;2015:659378.
6) Tang J, Huang H, Ji X, Zhu X, Li Y, She M, Yan S, Fung M, Li Z.. Involvement of IL-13 and tissue transglutaminase in liver granuloma and fibrosis post Schistosoma japonicum infection. Mediators of inflammation, 2014, Volume 2014 , 753483.
招生信息及联系方式
研究方向: 组织型转谷氨酰胺酶、NLRP3炎症小体活化与呼吸系统疾病的关系及其机制；模式生物黑腹果蝇转化到哺乳动物和人，研究宿主抵抗感染、-宿主-病原体的互作机制。
科研项目与成绩:获得国家自然科学基金、省自然科学基金、广州市科技计划项目的资助，还有呼吸病国家重点实验室开放课题、学校创新团队项目以及广东省高水平大学项目（免疫学）的资助。发表SCI文章多篇：例如，以通讯作者在Front Immunol、Mediators Inflamm、 Parasites & vectors，第一作者在J Biol Chem等杂志上发表学术论文。指导的研究生曾获得校级优秀研究生，研究生论文获得校级优秀、国际学术会议优秀论文等殊荣。
联系我们: lizi1002@gzhmu.edu.cn；020-37103804
