个人概况
姓名：蔡铭升 性别：男
职称：教授 导师资格：博士后、博士、硕士研究生导师
单位：基础医学院广州霍夫曼免疫研究所病原生物学与免疫学教研室
专业：免疫学、病原生物学、生物化学与分子生物学
学历：博士 毕业院校：中国科学院武汉病毒研究所
电子邮件：108629274@qq.com
通信地址：广州市番禺区新造镇广州医科大学
研究方向
病毒感染与免疫：主要是疱疹病毒特别是EB病毒和人I型单纯疱疹病毒（HSV-1）与宿主的相互作用、与肿瘤的发生发展的关系、病毒感染的天然免疫、病毒编码蛋白的亚细胞定位以及生物学功能等相关研究。
所获荣誉
1. 广州市高层次人才
2. 广州医科大学“南山学者”人才计划
3. 广州医科大学高水平大学学术骨干培育对象
4. 广东高校优秀青年创新人才培养计划
指导学生获得的项目和奖项
1. 指导的研究生获得研究生国家奖学金、优秀研究生称号、研究生企业奖学金和研究生学业奖学金等10多项奖学金及科研立项。
2. 指导本科生获得国家级、省级、市级和校级等科研项目和全国大学生设计大赛以及“挑战杯”广东大学生课外学术科技作品竞赛奖项40余项。
社会兼职
1. 国家科技专家库和教育部科技评价与评审信息系统专家
2. 国家自然科学基金、广东省自然科学基金评审专家，广东医学科技奖评审专家
3. 杂志审稿专家：Journal of Advanced Research、Frontiers in Immunology、Vaccine、Journal of Chromatography A、Archives of Biochemistry and Biophysics、BMCCell Biology、Infection Genetics and Evolution、Disease Markers、Virologica Sinica、BioMed Research International和Wuhan University Journal of Natural Sciences等。
4. 广东省热带医学学会理事、中国免疫学会、广东省免疫学会会员、中国微生物学会会员、中华医学会会员、湖北省免疫学会、细胞生物学学会会员。
科研项目
近5年主持国家级、省级、厅级、市级和校级等多个科研项目，研究经费充足：
1. 国家自然科学基金面上项目
2. 国家自然科学基金青年科学基金项目
3. 广东省自然科学基金面上项目（2项）、博士启动项目
4. 广东省教育厅特色创新项目、青年创新人才项目（育苗工程）
5. 广州市科技计划科学研究项目
6. 广州市属高校科研项目（2项）
7. 广州市高校创新创业训练项目
8. 广州医科大学博士启动项目
部分代表性第一和通讯作者论文：
1. Gong L, Ou XW, Hu L, Zhong JY, Li JJ, Deng SY, Li BL, Pan LX, Wang LD, Hong XJ, Luo WQ, Zeng QY, Zan J, Peng T(*),Cai MS(*), Li ML(*). The molecular mechanism of herpes simplex virus 1 UL31 in antagonizing the activity of IFN-β.Microbiology Spectrum, 10(1): e01883-21,2022
2. Chen T, Wang YF, Xu Z, Zou XM, Wang P, Ou XW, Li YW, Peng T, Chen DX, Li ML(*),Cai MS(*). Epstein-Barr virus tegument protein BGLF2 inhibits NF-κB activity by preventing p65 Ser536 phosphorylation.FASEB Journal, 33(9):10563-10576,2019
3. Li JJ, Guo YJ, Deng YX, Hu L, Li BL, Deng SY, Zhong JY, Xie L, Shi SX, Hong XJ, Zheng XL,Cai MS(*), Li ML(*).Subcellular localization of Epstein-Barr virus BLLF2 and its underlying mechanisms.Frontiers in Microbiology, 12:672192,2021
4. Cai MS, Liao ZM, Zou XM, Xu Z, Wang YF, Li T, Li YW, Ou XW, Deng YX, Guo YJ, Peng T, Li ML(*). Herpes simplex virus 1 UL2 inhibits the TNF-α-mediated NF-κB activity by interacting with p65/p50.Frontiers in Immunology,11: 549,2020
5. Wang P, Deng YX, Guo YJ, Xu Z, Li YW, Ou XW, Xie L, Lu MJ, Zhong JY, Li BL, Hu L, Deng SY, Peng T,Cai MS(*), Li ML(*). Epstein-Barr virus early protein BFRF1 suppresses IFN-β activity by inhibiting the activation of IRF3.Frontiers in Immunology, 11:513383,2020
6. Li ML, Liao ZM, Xu Z, Zou XM, Wang YF, Peng H, Li YW, Ou XW, Deng YX, Guo YJ, Gan WD, Peng T, Chen DX,Cai MS(*). The interaction mechanism between herpes simplex virus 1 glycoprotein D and host antiviral protein viperin.Frontiers in Immunology, 10: 2810,2019
7. Cai MS,Li ML, Zheng CF(*). Herpesviral infection and Toll-like receptor 2.Protein & Cell, 3(8): 590-601,2012
8. Cai MS, Li ML, Wang KZ, Wang S, Lu Q, Yan JH, Mossman KL, Lin RT, Zheng CF(*). The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway.Plos One, 8(1): e54586,2013
9. Cai MS, Deng SX, Li ML(*). Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes.Vaccine, 31(9):1353-1356,2013
10. Cai MS, Jiang S, Zeng ZC, Li XW, Mo CC, Yang YJ, Chen CK, Xie PP, Bian Y, Wang JL, Huang JL, Chen DX, Peng T, Li ML(*). Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22.Cell & Bioscience, 6: 3,2016
11. Li ML, Xu Z, Zou XM, Wang YF, Li YW, Ou XW, Deng YX, Guo YJ, Gan WD, Chen DX, Peng T, Xiao J,Cai MS(*). Intracellular distribution of pseudorabies virus UL2 and detection of its nuclear import mechanism.Biological Chemistry, 401(2): 309-317,2020
12. Cai MS, Wang P, Wang YF, Chen T, Xu Z, Zou XM, Ou XW, Li YW, Chen DX, Peng T, Li ML(*). Identification of the molecular determinants for nuclear import of PRV EP0.Biological Chemistry, 400(10): 1385-1394,2019
13. Cai MS, Huang ZB, Liao ZM, Chen T, Wang P, Jiang S, Chen DX, Peng T, Bian Y, Hong GD, Yang H, Zeng ZC, Li XW, Li ML(*). Characterization of the subcellular localization and nuclear import molecular mechanisms of herpes simplex virus 1 UL2.Biological Chemistry. 398(4): 509-517,2017
14. Cai MS, Jiang S, Li XW, Zeng ZC, Li ML(*). Characterization of the nuclear import mechanisms of HSV-1 UL31.Biological Chemistry, 397(6): 555-561,2016
15. Cai MS, Wang S, Xing JJ, Zheng CF(*). Characterization of the nuclear import and export signals, and subcellular transport mechanism of varicella-zoster virus ORF9.Journal of General Virology, 92(Pt 3): 621-626,2011
16. Cai MS, Wang S, Long J, Zheng CF(*). Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10.Medical Microbiology and Immunology, 201(1): 103-111,2012
17. Li ML, Jiang S, Mo CC, Wang JL, Huang JL, Zeng ZC, Li XW, Chen CK, Yang YJ, Peng T,Cai MS(*). Identification of molecular determinants for the nuclear import of pseudorabies virus UL31.Archives of Biochemistry and Biophysics,587: 12-17,2015
18. Cai MS, Zhao ZY, Yang L, Zhu JY, Cui W, Ma CL, Yuan ZQ, Li ML(*). Molecular property of the Epstein-Barr virusBFRF3gene.Virologica Sinica, 28(6): 368-372,2013
19. Li ML, Zhao ZY, Chen JH, Wang BY, Li Z, Li J,Cai MS(*). Characterization of synonymous codon usage bias in the pseudorabies virusUS1gene.Virologica Sinica, 27(5): 303-315,2012
20. Cai MS, Chen DX, Zeng ZC, Yang H, Jiang S, Li XW, Mai JY, Peng T, Li ML(*). Characterization of the nuclear import signal of herpes simplex virus 1 UL31.Archives of Virology, 161(9): 2379-2385,2016
21. Li ML, Jiang S, Wang JL, Mo CC, Zeng ZC, Yang YJ, Chen CK, Li XW, Cui W, Huang JL, Peng T,Cai MS(*). Characterization of the nuclear import and export signals of pseudorabies virus UL31.Archives of Virology, 160: 2591-2594,2015
22. Li ML, Cui W, Mo CC, Wang JL, Zhao ZY,Cai MS(*).Cloning, expression, purification, antiserum preparation and its characteristics of the truncated UL6 protein of herpes simplex virus 1.Molecular Biology Reports, 41(9): 5997-6002,2014
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