简介
陈建明教授
现任广州医科大学特聘教授，闽江学院海洋研究院常务副院长。2003年获得瑞士苏黎世大学博士学位，2004年至2008年,美国Scripps研究所作博士后研究。2009年至2017年任国家海洋局第三海洋研究所研究员，2012年至2017年国家海洋局海洋生物遗传资源重点实验室副主任。
Adjunct Professor of Sino-French Hoffmann Institute of Immunology, Professor and Deputy Director of Institute of Oceanography, Minjiang University. Dr. Chen got Ph.D in 2003 at University of Zurich and worked as Research Associate at Dept. of Immunology, The Scripps Research Institute from 2004 to 2008. From 2009 to 2017, he worked as a principle investigator at The Third Institute of Oceanography, State Oceanic Administration of China.
课题组研究方向
1）固有免疫信号通路的进化和适应性；
2）海洋生物活性物质包括软骨鱼纳米抗体和海洋微生物来源天然产物。
1) Evolution and adaptation of innate immunity signaling pathways;
2) Marine bioactive products including nanobodies of Chondrichthyes and natural products from marine microbes.
代表文章
1. Yao Y, Li X, Wang W, Liu Z, Chen J, Ding M, Huang X (2018) MRT, Functioning with NURF Complex, Regulates Lipid Droplet Size. Cell Rep. 24(11):2972-2984.
2. Wang W, Liao Y, Chen R, Hou Y, Ke W, Zhang B, Gao M, Shao Z, Chen J, Li F (2018) Chlorinated azaphilone pigments with antimicrobial and cytotoxic activities isolated from the deep sea derived fungus Chaetomium sp. NA-S01-R1.Mar Drugs. 16(2) pii: E61.
3. Liu G, Chen M, Yu C, Wang W, Yang L, Li Z, Wang W, Chen J (2017) Molecular cloning, characterization and functional analysis of a putative mitogen-activated protein kinase kinase kinase 4 (MEKK4) from blood clam Tegillarca granosa. Fish Shellfish Immunol. 66:372-381.
4. Pan C, Wang W, Yuan H, Yang L, Chen B, Li D, Chen J（2017）The immediate early protein WSV187 can influence viral replication via regulation of JAK/STAT pathway in Drosophila. Dev Comp Immunol. 72:89-96.
5. Li Z， Hao Q, Luo J，Xiong J， Zhang S, Wang T, Bai L, Wang W, Chen M, Wang W, Gu L, Lv K，Chen J. (2016) USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. Oncogene 35 (22):2902-2912.
6. Chen J, Xie C, Tian L, Hong L, Wu X and Han J (2010) The p38 pathway participates in Drosophila host defense against pathogenic bacteria and fungi. PNAS 107: 20774-20779.
