Brief Introduction

               Dr. Renjie Jiao

Director of Sino-French Hoffmann Institute, Professor, Principal Investigator

Prof. Renjie Jiao was born in Jiangsu, China in the year of 1965. He obtained his Bachelor of Science majoring in Cell Biology from Peking University in 1987; Master of Science majoring in Cell Biology from the same university in 1991; and his PhD of Molecular Genetics and Developmental Biology from the University of Zurich in 1999. After a few years of postdoc training in Switzerland, he started his own lab in 2004 at the Institute of Biophysics, Chinese Academy of Sciences. He moved to Sino-French Hoffmann Institute, Guangzhou Medical University in 2017. He is currently an associate editor of “Journal of Genetics and Genomics”. A grant reviewer for Cancer Research UK; Austrian National Science Foundation; National Science Foundation of China; Ministry of Science and Technology, China. An evaluation expert for scientific awards organizations as Xplorer Prize; Macao Science and Technology Awards. A paper reviewer for scientific journals like «Nature Communications»、«Development»、«Journal of Cell Science»、«Journal of Molecular Cell Biology»、«Theranostics». He has published more than 70 papers in scientific journal like Nature Cell Biol., Dev. Cell, Cell Res., Nat. Commun., Cancer Res., Development, Oncogene, J. Neurosci.

Research directions

AIM（Aging – Immunity - Metabolism）is the research direction in Jiao lab. Using Drosophila a model system, the central question is how the fly innate immunity is regulated with aging, metabolic and epigenetic signals integrated in the process of infection. Assaying techniques in the lab include, but not restricted to, methods in molecular biology, genetics, cell biology (light and electron microscopy), immunology, and high throughput -omics (single cell sequencing, metabolomics, proteomics etc.).

Selected publications in recent years

1. Wei C., C.-W. Phang and R. Jiao*.  2020.  Epigenetic regulation of Notch signaling during Drosophila development. Adv Exp Med Biol 1218: 59–76.

2. Wei C., Y. Yan, X. Miao and R. Jiao*.  2019.  Dissection and Lipid Droplets Staining of the Oenocytes in Drosophila Larvae.  Journal of Visualized Experiments (JoVE), e60606.

3. Yan Y., H. Wang, C. Wei, Y. Xiang, X. Liang, C. W. Phanga and R. Jiao*.  2019.  HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy.  J. Genet. Genomics, 46: 221 – 229.

4. Lo, P.-K., Y.-C. Huang, D. Corcoran, R. Jiao and W.-M. Deng.  2019.  Drosophila chromatin assembly factor 1 p105 and p180 subunits are required for follicle cell proliferation via inhibiting Notch signaling.  J. Cell Sci., 132: doi:10.1242/jcs.224170.

5. Chen, J., N. Xu, C. Wang, P. Huang, H. Huang, Z. Jin, Z. Yu, T. Cai, R. Jiao and R. Xi.  2018.  Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.  Nature Cell Biol., 20(2): 152-161.

6. Yan, Y., H. Wang, M. Hu, L. Jiang, Y. Wang, P. Liu, X. Liang, J. Liu, C. Li, A. Lindström-Battle, W.-M. Deng and R. Jiao*. 2017. HDAC6 suppresses age-dependent ectopic fat accumulation by Maintaining the proteostasis of PLIN2 in Drosophila.  Dev. Cell., 43: 99–111.

7. Xie, G., H. Chen, D. Jia, Z. Shu, W. Palmer, X. Zeng, S. Hou, R. Jiao* and W.-M. Deng*, 2017. The SWI/SNF complex protein Snr1 is a tumor suppressor in Drosophila imaginal tissues. Cancer Res., 77: 862-873.

8. Peng, Q., Y. Wang, M. Li, D. Yuan, M. Xu, C. Li, Z. Gong, R. Jiao* and L. Liu*.  2016. cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.  J. Neurosci.  36: 4635 - 4646.

9. Zhang, H.#, C. Li#, H. Chen, H. Wu, W. Dui, F. Dai, W.-M. Deng* and R. Jiao*.  2015. SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila.  Cell Res., 25: 93-109.

10. Xie, G., Z. Yu, D. Jia, R. Jiao* and W.-M. Deng*.  2014. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.   J. Cell Sci., 127: 3830 – 3839.

11. Yu, Z., H. Wu, H. Chen, R. Wang, X. Liang, J. Liu, C. Li, W.-M. Deng* and R. Jiao*. 2013. CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development.  Development, 140: 3635-3644.

12. Yu, Z., M. Ren, Z. Wang, B. Zhang, Y.S. Rong, R. Jiao* and G. Gao*. 2013. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila.  Genetics, 195: 289-291.

13. Dui, W., B. Wei, F. He, W. Lu, C. Li, X. Liang, J. Ma* and R. Jiao*.  2013.  The Drosophila F-box protein dSkp2 regulates cell proliferation through targeting Dacapo for degradation.  Mol. Biol. Cell, 24: 1676-1687.