彭涛教授个人简介
1. 简介（Introductions）
彭涛教授，武汉大学生化专业学士，美国德雷塞尔大学分子遗传学硕士，宾西法利亚大学病毒学博士，曾在斯克里普斯研究所及加州大学圣地亚哥分校从事博士后研究，后加入美国制药企业从事抗病毒药物研发工作。2004年回国加入中科院广州生物医药与健康研究院，任病毒免疫实验室主任。2014年加入广州医科大学，并在2014-2017年任中法霍夫曼免疫研究所首任所长。
彭涛教授2008年入选中科院“百人计划”，2013年入选“千人-计划”及“广州市创新领军人才”，并获2015年科学中国人年度人物及2014年中国侨联贡献奖。曾经担任广东省高水平大学重点建设项目“基础医学（免疫学）”负责人，科技部973课题负责人，国家科技重大专项课题负责人，科技部国际合作项目负责人，科学院重大项目课题负责人，广东省重大科技专项课题负责人。担任科技部973项目中期、结题评审专家。
在任职两届Antiviral Research编委，彭涛教授于2019年升任Antiviral Research编辑，并担任包括FEBS J, Journal of Virology近20个杂志审稿人。他主编了《核酸等温扩增技术及其应用》、《临床病毒学》等专著，获得包括国际专利“可溶性疱疹病毒蛋白复合体疫苗”在内的8项发明专利授权。在Journal of Virology, Hepatology, Cellular Microbiology, Antiviral Research 等国际期刊上发表近60篇SCI论文。
Professor Peng received his B.Sc. degree in Biochemistry from Wuhan University, M.Sc. degree in Molecular Genetics from Drexel University (Philadelphia, USA) in 1994, and Ph.D. in Virology from University of Pennsylvania (Philadelphia, USA) in 1998. He has been engaged in postdoctoral research in SCRIPPS and University of California San Diego, and then in the research and development of antiviral drugs in pharmaceutical companies in the United States. He joined Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences in 2004 as the Principal Investigator of the Laboratory of Viral Immunology. In 2014, he was recruited by GMU as Professor, and during 2014-2017, he has functioned as director of SFHI.
Prof. Peng was selected into the “Hundred Talent Program (Chinese Academy of Sciences)” (2008), and the “Thousand Talents Program” (2013). He was awarded Guangzhou “Innovative Leading Talents” (2013), “Scientific Chinese Annual Award” (2015), and “Overseas Chinese Contribution Award” (2014). He was supported by many grants such as the key construction project "basic medicine (immunology)" of Guangdong High-level University, the 973 project of the Ministry of Science and Technology, the major national research and development projects, the international cooperation projects of the Ministry of Science and Technology, the major science and technology projects of the academy of sciences, and the major science and technology projects of Guangdong province. He served as the mid-term and final evaluation expert for the project 973 of the Ministry of Science and Technology.
After served on its Editorial Board for two terms, he is now an Editor for the journal Antiviral Research. He also serves as reviewers of nearly 20 journals including FEBS J, Journal of Virology. He is the Chief Editor of “Isothermal Nucleic Acid Amplification Technology and Application” (a book designated for “isothermal nucleic acid amplification technology”, published by Science Press, China), and the Chief Editor of Clinical Virology (a book published by Science Press, China). He has obtained 8 patents including the international patent "Soluble Herpes Virus Protein Complex Vaccine". He has published nearly 60 scientific papers in the international Journal such as Journal of Virology, Hepatology, Cellular Microbiology, and Antiviral Research.
2. 主要研究方向（Research interests）
我们利用哺乳动物及果蝇研究平台鉴定参与抗病毒反应的保守的宿主因子。我们的研究目标是：（i）寻找并鉴定在果蝇及哺乳动物系统中参与抗病毒反应的保守的宿主因子；(ii) 基于对病毒宿主相互作用的深入研究建立抗病毒活性评价系统发掘更多的抗病毒药物靶点。
We used mammalian and drosophila research platforms to identify conserved host factors involved in antiviral responses. Our objective is to :(I) to identify conserved host factors involved in antiviral responses in drosophila and mammalian systems; (ii) to establish an antiviral activity evaluation system to explore more antiviral drug targets based on in-depth study of virus host interaction
3. 代表性论文（Selected publications）
[1] XU Y, MA S, HUANG Y, et al. Virus-like particle vaccines for poliovirus types 1, 2, and 3 with enhanced thermostability expressed in insect cells [J]. Vaccine, 2019, 37(17): 2340-7.
[2] XIAO J, LONG F, PENG T, et al. Development and potential application of a simultaneous multiplex assay of Golgi protein 73 and alpha-fetoprotein for hepatocellular carcinoma diagnosis [J]. European review for medical and pharmacological sciences, 2019, 23(8): 3302-10.
[3] QIN R, LONG F, XIAO X, et al. Sputum Autoantibodies Are More Relevant in Autoimmune Responses in Asthma than Are Serum Autoantibodies [J]. Allergy, asthma & immunology research, 2019, 11(3): 406-21.
[4] LI J, MA C, LONG F, et al. Parkin impairs antiviral immunity by suppressing the mtROS-NLRP3 axis and anti-viral inflammation [J]. iScience, 2019,
[5] CAI M, WANG P, WANG Y, et al. Identification of the molecular determinants for nuclear import of PRV EP0 [J]. Biological chemistry, 2019,
[6] XIA S, ZHU Z, GUAN W J, et al. Correlation between upper and lower airway inflammations in patients with combined allergic rhinitis and asthma syndrome: A comparison of patients initially presenting with allergic rhinitis and those initially presenting with asthma [J]. Experimental and therapeutic medicine, 2018, 15(2): 1761-7.
[7] LIU L Y, LIU J K, SU W H, et al. A novel chloro-substituted pentenamide from the fruiting bodies of Amanita virgineoides [J]. Journal of Asian natural products research, 2018, 20(1): 86-91.
[8] LI M, CHEN T, ZOU X, et al. Characterization of the Nucleocytoplasmic Transport Mechanisms of Epstein-Barr Virus BFLF2 [J]. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, 51(4): 1500-17.
[9] GOTO A, OKADO K, MARTINS N, et al. The Kinase IKKbeta Regulates a STING- and NF-kappaB-Dependent Antiviral Response Pathway in Drosophila [J]. Immunity, 2018, 49(2): 225-34 e4.
[10] CHEN Z, SUN L, CHEN H, et al. Dorsal Vagal Complex Modulates Neurogenic Airway Inflammation in a Guinea Pig Model With Esophageal Perfusion of HCl [J]. Frontiers in physiology, 2018, 9(536.
[11] ZHOU L, CHEN D, HUANG X M, et al. Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation [J]. Frontiers in cellular neuroscience, 2017, 11(281.
[12] XU Y, MA S, ZHU L, et al. Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model [J]. Antiviral research, 2017, 137(67-75.
[13] LI T, LIU L, WU H, et al. Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb [J]. Antiviral research, 2017, 144(273-80.
[14] HU L, LI J, CAI H, et al. Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles [J]. Antiviral research, 2017, 148(5-14.
[15] CAI M, LIAO Z, CHEN T, et al. Characterization of the subcellular localization of Epstein-Barr virus encoded proteins in live cells [J]. Oncotarget, 2017, 8(41): 70006-34.
[16] ZHOU N, PAN T, ZHANG J, et al. Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) [J]. The Journal of biological chemistry, 2016, 291(17): 9218-32.
[17] CAI M, JIANG S, ZENG Z, et al. Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22 [J]. Cell & bioscience, 2016, 6(3.
[18] CAI M, CHEN D, ZENG Z, et al. Characterization of the nuclear import signal of herpes simplex virus 1 UL31 [J]. Archives of virology, 2016, 161(9): 2379-85.
[19] CAI H, YAO W, LI L, et al. Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A [J]. Scientific reports, 2016, 6(27778.
[20] LI M, JIANG S, WANG J, et al. Characterization of the nuclear import and export signals of pseudorabies virus UL31 [J]. Archives of virology, 2015, 160(10): 2591-4.
[21] LI M, JIANG S, MO C, et al. Identification of molecular determinants for the nuclear import of pseudorabies virus UL31 [J]. Archives of biochemistry and biophysics, 2015, 587(12-7.
[22] YAO W, CAI H, LI X, et al. Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1alpha/liver-specific PGC-1alpha upregulation [J]. Journal of virology, 2014, 88(15): 8361-74.
[23] LI X, JIANG H, QU L, et al. Hepatocyte nuclear factor 4alpha and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus [J]. Journal of virology, 2014, 88(1): 612-27.
[24] HU L, YAO W, WANG F, et al. GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion [J]. PLoS ONE, 2014, 9(3): e90553.
[25] PAN H H, YU X T, LI T, et al. Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion [J]. International journal of medicinal mushrooms, 2013, 15(1): 29-38.
[26] LI T, PENG T. Traditional Chinese herbal medicine as a source of molecules with antiviral activity [J]. Antiviral research, 2013, 97(1): 1-9.
