Di Chen *, Xiao Lan , Xiaoming Huang , Jieqing Huang , Xiaojing Zhou , Jiyong Liu , Jules A Hoffmann*. Methuselah like 1, a Drosophila homologue of Mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies. PNAS, 2023, (in press).
Di Chen*, Xiao Lan, Xiaoming Huang, Jieqing Huang, Xiaojing Zhou, Zhichao Miao, Yuting Ma, Akira Goto, Shanming Ji, Jules A. Hoffmann*. Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila. Journal of Innate Immunity, 2023, 15:442–467.
Di Chen (#)*, Arghyashree Roychowdhury-Sinha, Pragya Prakash, Xiao Lan, Wenmin Fan, Akira Goto*, Jules A. Hoffmann*. A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defences. PNAS, 2021, 118.
Goto A#*, Okado K#, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL*. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2020 Jan 14;52(1):200.
FRAITURE M, BAXTER RH, STEINERT S, CHELLIAH Y, FROLET C, QUISPE-TINTAYA W, HOFFMANN JA, BLANDIN SA, LEVASHINA EA (2009). Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host Microbe. Vol 5, 273-84.
DEDDOUCHE S, MATT N, BUDD A, MUELLER S, KEMP C, GALIANA-ARNOUX D, DOSTERT C, ANTONIEWSKI C, HOFFMANN JA, IMLER JL (2008). The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in Drosophila. Nature Immunology. Vol 9, 1425-1432.
HOFFMANN JA (2007). Antifungal defense in Drosophila. Nature Immunology. Vol 8, 543-545.
LEMAITRE B, HOFFMANN JA (2007). The host defense of Drosophila melanogaster. Annual Review of Immunology. Vol 25, 697-743.
FERRANDON D, IMLER JL, HETRU C, HOFFMANN JA (2007). The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nature Reviews of Immunology. Vol 7, 862-874.
BEUTLER B, EIDENSCHENK C, CROZAT K, IMLER JL, TAKEUCHI O, HOFFMANN JA, AKIRA S (2007). Genetic analysis of resistance to viral infection. Nature Reviews of Immunology. Vol 7, 753-766.
FROLET C, THOMA M, BLANDIN S, HOFFMANN JA, LEVASHINA EA (2006). Boosting NF-kB Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei. Immunity. Vol 25, 677-685.
DOSTERT C, JOUANGUY E, IRVING P, TROXLER L, GALIANA-ARNOUX D, HETRU C, HOFFMANN JA, IMLER JL (2005). The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila. Nature Immunol. Vol 6, 946-953.
LIGOXYGAKIS P, PELTE N, HOFFMANN JA, REICHHART JM, (2002), Activation of Drosophila Toll during fungal infection by a novel blood serine protease, Science. Vol 297, 114-116
GOTTAR M, GOBERT V, MICHEL T, BELVIN M, DUYK G, HOFFMANN JA, FERRANDON D, ROYET J, (2002). The Drosophila immune response against Gram-negative bacteria is médiated by a peptidoglycan recognition protein, Nature. Vol 416, 641-644
MICHEL T, REICHHART JM, HOFFMANN JA & ROYET J. (2001). Drosophila Toll is activated by Gram-positive bacteria via a circulating peptidoglycan recognition protein. Nature. Vol 414, 756-759
GEORGEL, P., NAITZA S., KAPPLER, C., FERRANDON, D., ZACHARY, D., SWIMMER, C., KOPCZYNSKI, C., DUYK, G., REICHHART, J-M., AND HOFFMANN, J.A. ( 2001). Drosophila Immune Deficiency (IMD) is a Death Domain Protein that Activates Antibacterial Defence and Can Promote Apoptosis. Developmental Cell. Vol 1, 1-20, 503-514
TZOU P, OHRESSER S, FERRANDON D, CAPOVILLA M, REICHHART JM, LEMAITRE B, HOFFMANN JA & IMLER JL (2000). Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. Vol 13 737-748
RUTSCHMANN S, JUNG AC, ZHOU R, SILVERMAN N, HOFFMANN JA & FERRANDON D (2000). Role of Drosophila IKKg in a Toll-independent antibacterial immune response. Nature Immunol. Vol 1 342-347
HOFFMANN JA, KAFATOS FC, JANEWAY CA JR & EZEKOWITZ RAB (1999). Phylogenetic perspectives in innate immunity. Science. Vol 284 1313-1318
DIMARCQ JL, BULET P, HETRU C & HOFFMANN JA (1998). Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers (Peptide Science). Vol 47 465-477
FERRANDON D, JUNG AC, CRIQUI MC, LEMAITRE B, UTTENWEILER-JOSEPH S, MICHAUT L, REICHHART JM & HOFFMANN JA (1998). A GFP-drosomycin reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J. Vol 17 1217-1227
LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM & HOFFMANN JA (1996). The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in Drosophila adults. Cell. Vol 86 973-983
FRANC N, DIMARCQ JL, LAGUEUX M, HOFFMANN JA & EZEKOWITZ A (1996). Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. Vol 4 431-443
LEMAITRE B, KROMER-METZGER E, MICHAUT L, NICOLAS E, MEISTER M, GEORGEL P, REICHHART JM & HOFFMANN JA (1995). A recessive mutation, immune-deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. Vol 92 9465-9469
DIMARCQ JL, HOFFMANN D, MEISTER M, BULET P, LANOT R, REICHHART JM & HOFFMANN JA (1994). Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity. Eur. J. Biochem. Vol 221 201-209
J.A. HOFFMANN & D. HOFFMANN (1990). The inducible antibacterial peptides of dipteran insects. Res. Immunol. Vol 141 910-918
M. LAGUEUX, L. LWOFF, M. MEISTER, F. GOLTZENÉ & J.A. HOFFMANN (1990). cDNAs from neurosecretory cells of brains of Locusta migratoria (Insecta, Orthoptera) encoding a novel member of the superfamily of insulins. Eur. J. Biochem. Vol 187 249-254
J. LAMBERT, E. KEPPI, J.L. DIMARCQ, C. WICKER, J.M. REICHHART, B. DUNBAR, P. LEPAGE, A. VAN DORSSELAER, J.A. HOFFMANN, J. FOTHERGILL & D. HOFFMANN (1989). Insect immunity. Isolation from immune blood of the Dipteran Phormia terranovae of two novel antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides. Proc. Nat. Acad. Sci. Vol 86 262-266
M.F. COSTET, M. EL ACHOURI, M. CHARLET, R. LANOT, P. BENVENISTE & J.A. HOFFMANN (1987). Ecdysteroid biosynthesis and embryonic development are disturbed in insects (Locusta migratoria) reared on plant diet (Triticum sativum) with a selectively modified sterol profile. Proc. Nat. Acad. Sci. Vol 84 643-647
G. TSOUPRAS, B. LUU & J.A. HOFFMANN (1982). Isolation and identification of three ecdysteroid conjugates with a C-20 hydroxy group in eggs of Locusta migratoria. Steroids. Vol 40 51-560
P. KARLSON, J. KOOLMAN & J.A. HOFFMANN (1975). Biochemistry of ecdysone. Amer. Zool. Vol 15 49-59
J.A. HOFFMANN, J. KOOLMAN, P. KARLSON & P. JOLY (1974). Molting hormone titer and metabolic fate of injected ecdysone during the fifth larval instar and in adults of Locusta migratoria. Gen. Compar. Endocri. Vol 2 90-97
J.A. HOFFMANN (1973). Blood-forming tissues in Orthopteran Insects : an analogue to Vertebrate hemopoietic organs. Experientia. Vol 29 50-51
J.A. HOFFMANN (1970). Les organes hématopoiétiques de deux Insectes Orthoptères :Locusta migratoria et Gryllus bimaculatus. Z. Zellforsch. Vol 106 451-472
